Drug intelligence / Profile preview

[D-(CH2)5,Tyr(Me)2,Orn8]vasotocin

Development stage
Unknown
Modality
Peptides
Administration
Intravenous, Intracerebroventricular
01

Overview

This is a synthetic analog of vasotocin (arginine vasotocin, AVT), which is a neurohypophyseal peptide hormone found in non-mammalian vertebrates. The nomenclature indicates specific modifications to the vasotocin structure: a D-amino acid substitution with a 5-carbon methylene bridge, a methylated tyrosine at position 2, and ornithine substituted for arginine at position 8. Vasotocin is homologous to mammalian vasopressin and oxytocin, and acts as an endocrine regulator for water balance, osmotic homeostasis, and is involved in social and sexual behavior. This synthetic analog was likely designed to modify the pharmacological properties of native vasotocin, potentially altering receptor selectivity, duration of action, or metabolic stability.

02

Targets

Oxytocin receptorAVPR1A (Arginine vasopressin receptor 1A)AVPR1B (Vasopressin V1b Receptor)AVPR2 (Arginine vasopressin V2 receptor)

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